U.S. PATENT NO. 9,468,659 AND PATENTS PENDING

  • Improve Cartilage Health
  • Relieve Discomfort
  • Maintain Normal Joint Function
  • Increase Mobility
  • 60 capsules for 1 month



What is Arthritis?

knee pain
Arthritis is a common disease resulting in inflammation that breaks down the lining of joints and cartilage. Osteoarthritis is the most common form of arthritis. It is the result of aging "wear and tear" and trauma to the joint, such as sports injuries or fractures. Autoimmune arthritides such as rheumatoid arthritis result when the body’s immune system attacks itself. Inflammatory Th17 cells are playing a prominent role in autoimmune related disorders such as Rheumatoid Arthritis, Psoriasis, Multiple Sclerosis (20696013). Osteoarthritis (OA) and rheumatoid arthritis (RA) are characterized by joint inflammation and cartilage degradation. Mesenchymal Stem Cells (MSCs) are responsible for rebuilding cartilage breakdown. Although stem cells (MSCs) are resident in the superficial zone of articular cartilage, damaged tissue does not possess the capacity for regeneration. The high levels of pro-inflammatory cytokines present in OA/RA joints may impede the chondrogenic differentiation of MSCs. Inflammatory cytokines such as Interleukin (IL)-1β activates the transcription factor, nuclear factor-kB (NF-kB), which in turn activates proteins involved in matrix degradation, inflammation and apoptosis. Stem Cure Formula®  Joint Support contains natural phytochemicals capable of inhibiting IL-1β-induced activation of NF-kB and expression of apoptotic and pro-inflammatory genes in chondrocytes. (20594343)

What are Symptoms of Arthritis?


Major complaints of individuals with arthritis include joint pain, swelling, warmth, weakness, giving way of joint, instability, catching, popping, stiffness, poor sleep, muscle pain and fatigue.
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Current Treatment of Arthritis


Standard treatment has relied on relieving symptoms by exercise, braces, weight loss, medications, and surgery including total joint replacement. Medications such as non-steroidal anti-inflammatory drugs (NSAIDs) have risks that include the stomach, cardiovascular system and kidneys leading to ulcers, heart attacks and kidney failure (Table 1). There is no disease modifying treatment for osteoarthritis (http://www.aaos.org/Research/guidelines/GuidelineOAKnee.asp). Stem Cure Formula®  Joint Support contains natural phytochemicals capable of inhibiting IL-1β-induced activation of NF-kB and expression of apoptotic and pro-inflammatory genes in chondrocytes (20594343) which may reduce joint inflammation and promote cartilage regeneration. Total joint replacements though effective are major operations with significant risks and limited duration.  

Limitations of Current Medicine

The most commonly prescribed inflammatory/arthritis medications are non-steroidal anti inflammatory drugs (NSAIDs). NSAIDs include over the counter products such as ibuprofen (Mortrin/Advil), naproxen (Aleve), aspirin, and prescription drugs such as Naprosyn and Celebrex (celecoxib). The purpose of these medications is to treat inflammation and pain. These medications are associated with severe side effects (Table 1). In fact, one popular NSAID, Vioxx (rofecoxib) was taken off the market due to increased risk of heart attack and stroke in 2004.

Table 1. The side effects of current treatments for pain/inflammatory conditions
Acetaminophen (Tylenol®) NSAIDs
acetaminophen-associated overdoses account for about 56,000 emergency room visit and 26,000 hospitalizations yearly and more than 450 deaths from liver failure (16294364) nausea, heartburn, ingestion, abdominal pain, bleeding ulcer (GI complaints)* 16,500 people per year die as a result of NSAID-associated gastrointestinal complications (18239373)
No. 1 cause of acute liver failure heart attack, stroke (cardiovascular events), congestive heart failure, atrial fibrillation (24713211)
kidney toxicity kidney damage
* Estimated 107,000 patients are hospitalized annually for NSAID-related GI complications (9715832)

Regarding supplements, there are many on the market with claims of benefit for joint complaints and other health conditions. Many supplements have unfounded health claims. Many natural substances have yet to be scrutinized in scientific evidence-based research studies. Also, many supplements that were claimed to be beneficial have shown no clinically important difference once studied. For example, some of the most commonly used supplements for arthritis, glucosamine, and chondroitin sulfate have shown no clinically important difference in pain or function as compared with placebo. 

Glucosamine and chondroitin sulfate are NO BETTER than Placebo in NIH funded GAIT clinical study.



Over 2 years, no treatment achieved a clinically important difference in WOMAC pain or function as compared with placebo. (PMID: 20525840)


Why Stem Cure Formula®  Joint Support?


Stem Cure Formula
®  Joint Support was developed by a Board Certified Orthopedic Surgeon and  Stem Cells Researchers. Stem Cure Formula®  Joint Support is a paradigm shift in joint health. To support joint health, it is felt that keeping the cells that replenish the tissues (mesenchymal stem cells and cartilage/bone cells) healthy is important. Multiple scientific studies demonstrate supplements (referenced below) in Stem Cure Formula® Joint Support protects the cells and may promote chondrogenic differentiation of mesenchymal stem cells (MSC) (20594343). For decades, watching the progression of joint destruction in individuals go unabated and unaddressed by current treatment lead to the research and investigations of alternative options available now to treat and possibly halt the deterioration and improve this disease. Stem Cure Formula®Joint Support revolutionizes current thought and approach to joint health.

 
Individual supplements* of Stem Cure Formula™ Joint Support Clinically shown to be as effective as NSAID (Diclofenac)
joint-support-effective
Stem Cure Formula® Joint Support
Contains: Vitamin D, Lactobacillus rhamnosus, Curcumin, Boswellia Extract, Ginger [nutrition-label id=844] Each serving contains 10 billion live cells at time of manufacture. Other Ingredients: Hypromellose (Capsule), Rice Flour, Magnesium Stearate. Contains:  Milk (2.3 parts/million)

Individual supplements* of Stem Cure Formula Joint Support clinically shown to improve function
womac chartStem Cure Formula®  Joint Support combines a probiotic with natural supplements. These individual components have demonstrated protection against oxidative stress, decreased inflammation, and regulation of the immune system in scientific studies. Individual components of Stem Cure Formula® Joint Support have been shown in 2014 article “Efficacy and safety of Curcuma domestica extract compared with ibuprofen in patients with knee osteoarthritis: a multicenter study” (24672232) in 367 patients with osteoarthritis of the knee to decrease pain and stiffness and improve function. Stem Cure Formula®  Joint Support combines a probiotic with natural supplements. These individual supplements have demonstrated protection against oxidative stress, decreased inflammation, and regulation of the immune system in scientific studies. Individual components in Stem Cure Formula®  Joint Support have been shown in a randomized double blind placebo controlled crossover study to assess the efficacy, safety, and tolerability in 30 patients with osteoarthritis of the knee to :
  • Decrease pain
  • Increase joint movement
  • Decrease joint swelling
  • Clinically proven safety

Individual supplements * of Stem Cure Formula Joint Support clinically shown to decrease pain
joint-support-knee-pain

Individual supplements* of Stem Cure Formula Joint Support clinically shown to increase joint movement
joint-support-movement

Individual supplements* of Stem Cure Formula Joint Support clinically shown to decrease joint swelling
swelling

Individual supplements* of Stem Cure Formula Joint Support clinically proven safety