U.S. PATENT NO. 9,468,659 AND PATENTS PENDING


Stem Cure Formula® Joint Support is a blend of a probiotic and natural supplements consisting of Lactobacillus rhamnosus, Curcumin, Ginger, Vitamin D and Boswellia Extract.  

Multiple scientific studies demonstrate the individual components in Stem Cure Formula® protects the cells and tissues. Stem Cure Formula® Joint Support revolutionizes current thought and approach to supporting joint health.

PROBIOTIC, LACTOBACILLUS RHAMNOSUS

probiotic

Lactobacillus rhamnosus is a unique probiotic strain that has been studied extensively in the medical literature. 2162919018181732

Lactobacillus rhamnosus attenuates various types of Arthritis. 22484803

Lactobacillus rhamnosus functions as anti-oxidant which may aid health of cartilage cells. 19660542

Lactobacillus rhamnosus decreases inflammatory cytokines such as TNF-α which may prevent damage to cartilage and joint. 12675685

Lactobacillus rhamnosus has even shown ability to turn off inflammatory genes which cause pain and stiffness in Arthritis. 21499799

Lactobacillus rhamnosus has beneficial effect in Rheumatoid arthritis. 21629190

Multiple scientific studies demonstrate the individual components in Stem Cure Formula® protects the cells and tissues. Stem Cure Formula® Joint Support revolutionizes current thought and approach to supporting joint health.

CURCUMIN

Curcumin

Curcumin extract was found to be safe and equally effective as NSAID in treatment of osteoarthritis of knee. 19678780

Curcumin reduces inflammatory cytokines on cartilage. 24555068  

Curcumin functions anti-inflammatory. 23136720

Curcumin promotes cartilage formation from mesenchymal stem cells. 20594343

Curcumin has demonstrated anti-arthritic effect in animal model. 24138213

Curcumin reduces inflammation in the synovial lining of human joints. 23347846

Curcumin protects against collagen-induced arthritis. 23184090

Curcumin has therapeutic effect for treatment of osteoarthritis. 23487030

Multiple scientific studies demonstrate the individual components in Stem Cure Formula® protects the cells and tissues. Stem Cure Formula® Joint Support revolutionizes current thought and approach to supporting joint health.

 

GINGER

Ginger therapy has demonstrated a marked relief of osteoarthritis symptoms and appears safe over the long term. 24476702

Ginger protects joint inflammation by reducing inflammatory cytokines in rheumatoid arthritis. 23819216

Ginger has demonstrated in-vitro study in osteoarthritis and rheumatoid arthritis to be as effective as the powerful steroid, betamethasone. 23365744

Ginger has demonstrated in human clinical studies to be as effective as diclofenac (NSAID) with less side effects (stomach irritation). 22784345

Ginger has antioxidant and protective effects against acetaminophen as demonstrated in this animal study. 23927622

Multiple scientific studies demonstrate the individual components in Stem Cure Formula® protects the cells and tissues. Stem Cure Formula® Joint Support revolutionizes current thought and approach to supporting joint health.

VITAMIN D

Vitamin D levels positively associated with improved knee cartilage volume. 19404958

Vitamin D receptor regulates inflammation in osteoarthritic cartilage. 11467890

Vitamin D receptor regulates inflammation in rheumatoid arthritis

model. 21415051

Vitamin D appears to mediate anti-inflammatory action on synovial lining cells beneficially. 24348674

Vitamin D levels are directly associated with bone mineral density. 20718769

Longitudinal BMD loss is associated with progressive cartilage loss in knees with OA. 23494470

Multiple scientific studies demonstrate the individual components in Stem Cure Formula® protects the cells and tissues. Stem Cure Formula® Joint Support revolutionizes current thought and approach to supporting joint health.

BOSWELLIA EXTRACT

Boswellia Extract provides significant improvements in pain score and functional ability in osteoarthritis. 12622457

Boswellia Extract reduces pain and improves physical functioning in osteoarthritis patients. 24469975

Boswellia Extract is an immune-modulator and reduces Th17 differentiation. 12622457

Boswellia mix blocks inflammation related cartilage matrix breakdown, increases aggrecan and type II collagen in human osteoarthritis chondrocytes. 21854562

Boswellia Extract modulates immune system. 20696559

Boswellia Extract inhibits inflammation differently than NSAID, can be safe alternative. 17024588

Boswellia Extract derivative inhibits cartilage degrading enzyme (MMP) and regulates inflammation (ICAM-1) in human osteoarthritis study. 21060724

Boswellia Extract has anti-inflammatory, anti-arthritic and analgesic activity. 12622457

Boswellia Extract in a randomized double blinded placebo controlled study demonstrated statically significant and clinically relevant improvements (all patients had decreased knee pain, increased knee flexion and walking distance) in patients with osteoarthritis knee. 12622457

Boswellic acid down regulates gene expression of fat formation in adipocytes. 23313487

Boswellia Extract has anti-arthritic and anti-inflammation effects via suppression of pro-inflammatory cytokines. 15970410

Boswellia Extract has potent anti-inflammatory properties both in vitro as well as in vivo. 16677108

Boswellia Extract decreases joints inflammation and spinal arthritis in animal model. 14994484

Oral and topical boswellic acid attenuates mouse osteoarthritis. PMC3992997



STEM CURE FORMULA® JOINT SUPPORT and You!

Inflammation plays a pivotal role in all arthritic conditions. Both osteoarthritis and rheumatoid arthritis are inflammatory conditions. The immune system is responsible for controlling inflammation.  Individual supplements in Stem Cure Formula® Joint Support have been shown to function as immune-modulators and reduce T-helper 17 (Th-17) differentiation.  Although many patients will begin to see improvement within a few days to weeks with these treatments, it is important to realize that the response to inflammation can take months to downregulate maximally.  For patients with RHEUMATOID ARTHRITIS and other AUTOIMMUNE JOINT DISORDERS where the body develops antibodies to itself and ultimately attacks itself, the T-helper 17 (Th-17) cells play an instrumental role in the inflammatory condition and disease process. Th-17 cells are a subset of T-helper cells that produce interleukin (IL)-17. Interleukin-17 is an inflammatory cytokine which results in destructive tissue damage to the cartilage and joint. Individual supplements in Stem Cure Formula® Joint Support have been shown to function as immune-modulators and reduce Th-17 differentiation.  Because the Th-17 can live up to six months and pass along their programmed cellular destruction into memory cells. The improvement for rheumatoid arthritis and other autoimmune joint disorders may take longer. For this reason, it is STRONGLY RECOMMENDED that customers try STEM CURE FORMULA® JOINT SUPPORT "daily" for at least 3 months.

 

Stem Cure Formula® Joint Support

Contains: Vitamin D, Lactobacillus rhamnosus, Curcumin, Boswellia Extract, Ginger Each serving contains 10 billion live cells at time of manufacture.Other Ingredients: Hypromellose (Capsule), Rice Flour, Magnesium Stearate. Contains:  Milk (2.3 parts/million)

Click for our Joint Support product brochure





U.S. PATENT NO. 9,468,659 AND PATENTS PENDING

  • Improve Cartilage Health
  • Relieve Discomfort
  • Maintain Normal Joint Function
  • Increase Mobility
  • 60 capsules for 1 month



What is Arthritis?

knee pain
Arthritis is a common disease resulting in inflammation that breaks down the lining of joints and cartilage. Osteoarthritis is the most common form of arthritis. It is the result of aging "wear and tear" and trauma to the joint, such as sports injuries or fractures. Autoimmune arthritides such as rheumatoid arthritis result when the body’s immune system attacks itself. Inflammatory Th17 cells are playing a prominent role in autoimmune related disorders such as Rheumatoid Arthritis, Psoriasis, Multiple Sclerosis (20696013). Osteoarthritis (OA) and rheumatoid arthritis (RA) are characterized by joint inflammation and cartilage degradation. Mesenchymal Stem Cells (MSCs) are responsible for rebuilding cartilage breakdown. Although stem cells (MSCs) are resident in the superficial zone of articular cartilage, damaged tissue does not possess the capacity for regeneration. The high levels of pro-inflammatory cytokines present in OA/RA joints may impede the chondrogenic differentiation of MSCs. Inflammatory cytokines such as Interleukin (IL)-1β activates the transcription factor, nuclear factor-kB (NF-kB), which in turn activates proteins involved in matrix degradation, inflammation and apoptosis. Stem Cure Formula®  Joint Support contains natural phytochemicals capable of inhibiting IL-1β-induced activation of NF-kB and expression of apoptotic and pro-inflammatory genes in chondrocytes. (20594343)

What are Symptoms of Arthritis?


Major complaints of individuals with arthritis include joint pain, swelling, warmth, weakness, giving way of joint, instability, catching, popping, stiffness, poor sleep, muscle pain and fatigue.
7396616_l shutterstock_157128563-2 11222985_med

Current Treatment of Arthritis


Standard treatment has relied on relieving symptoms by exercise, braces, weight loss, medications, and surgery including total joint replacement. Medications such as non-steroidal anti-inflammatory drugs (NSAIDs) have risks that include the stomach, cardiovascular system and kidneys leading to ulcers, heart attacks and kidney failure (Table 1). There is no disease modifying treatment for osteoarthritis (http://www.aaos.org/Research/guidelines/GuidelineOAKnee.asp). Stem Cure Formula®  Joint Support contains natural phytochemicals capable of inhibiting IL-1β-induced activation of NF-kB and expression of apoptotic and pro-inflammatory genes in chondrocytes (20594343) which may reduce joint inflammation and promote cartilage regeneration. Total joint replacements though effective are major operations with significant risks and limited duration.  

Limitations of Current Medicine

The most commonly prescribed inflammatory/arthritis medications are non-steroidal anti inflammatory drugs (NSAIDs). NSAIDs include over the counter products such as ibuprofen (Mortrin/Advil), naproxen (Aleve), aspirin, and prescription drugs such as Naprosyn and Celebrex (celecoxib). The purpose of these medications is to treat inflammation and pain. These medications are associated with severe side effects (Table 1). In fact, one popular NSAID, Vioxx (rofecoxib) was taken off the market due to increased risk of heart attack and stroke in 2004.

Table 1. The side effects of current treatments for pain/inflammatory conditions
Acetaminophen (Tylenol®) NSAIDs
acetaminophen-associated overdoses account for about 56,000 emergency room visit and 26,000 hospitalizations yearly and more than 450 deaths from liver failure (16294364) nausea, heartburn, ingestion, abdominal pain, bleeding ulcer (GI complaints)* 16,500 people per year die as a result of NSAID-associated gastrointestinal complications (18239373)
No. 1 cause of acute liver failure heart attack, stroke (cardiovascular events), congestive heart failure, atrial fibrillation (24713211)
kidney toxicity kidney damage
* Estimated 107,000 patients are hospitalized annually for NSAID-related GI complications (9715832)

Regarding supplements, there are many on the market with claims of benefit for joint complaints and other health conditions. Many supplements have unfounded health claims. Many natural substances have yet to be scrutinized in scientific evidence-based research studies. Also, many supplements that were claimed to be beneficial have shown no clinically important difference once studied. For example, some of the most commonly used supplements for arthritis, glucosamine, and chondroitin sulfate have shown no clinically important difference in pain or function as compared with placebo. 

Glucosamine and chondroitin sulfate are NO BETTER than Placebo in NIH funded GAIT clinical study.



Over 2 years, no treatment achieved a clinically important difference in WOMAC pain or function as compared with placebo. (PMID: 20525840)


Why Stem Cure Formula®  Joint Support?


Stem Cure Formula
®  Joint Support was developed by a Board Certified Orthopedic Surgeon and  Stem Cells Researchers. Stem Cure Formula®  Joint Support is a paradigm shift in joint health. To support joint health, it is felt that keeping the cells that replenish the tissues (mesenchymal stem cells and cartilage/bone cells) healthy is important. Multiple scientific studies demonstrate supplements (referenced below) in Stem Cure Formula® Joint Support protects the cells and may promote chondrogenic differentiation of mesenchymal stem cells (MSC) (20594343). For decades, watching the progression of joint destruction in individuals go unabated and unaddressed by current treatment lead to the research and investigations of alternative options available now to treat and possibly halt the deterioration and improve this disease. Stem Cure Formula®Joint Support revolutionizes current thought and approach to joint health.

 
Individual supplements* of Stem Cure Formula™ Joint Support Clinically shown to be as effective as NSAID (Diclofenac)
joint-support-effective
Stem Cure Formula® Joint Support
Contains: Vitamin D, Lactobacillus rhamnosus, Curcumin, Boswellia Extract, Ginger [nutrition-label id=844] Each serving contains 10 billion live cells at time of manufacture. Other Ingredients: Hypromellose (Capsule), Rice Flour, Magnesium Stearate. Contains:  Milk (2.3 parts/million)

Individual supplements* of Stem Cure Formula Joint Support clinically shown to improve function
womac chartStem Cure Formula®  Joint Support combines a probiotic with natural supplements. These individual components have demonstrated protection against oxidative stress, decreased inflammation, and regulation of the immune system in scientific studies. Individual components of Stem Cure Formula® Joint Support have been shown in 2014 article “Efficacy and safety of Curcuma domestica extract compared with ibuprofen in patients with knee osteoarthritis: a multicenter study” (24672232) in 367 patients with osteoarthritis of the knee to decrease pain and stiffness and improve function. Stem Cure Formula®  Joint Support combines a probiotic with natural supplements. These individual supplements have demonstrated protection against oxidative stress, decreased inflammation, and regulation of the immune system in scientific studies. Individual components in Stem Cure Formula®  Joint Support have been shown in a randomized double blind placebo controlled crossover study to assess the efficacy, safety, and tolerability in 30 patients with osteoarthritis of the knee to :
  • Decrease pain
  • Increase joint movement
  • Decrease joint swelling
  • Clinically proven safety

Individual supplements * of Stem Cure Formula Joint Support clinically shown to decrease pain
joint-support-knee-pain

Individual supplements* of Stem Cure Formula Joint Support clinically shown to increase joint movement
joint-support-movement

Individual supplements* of Stem Cure Formula Joint Support clinically shown to decrease joint swelling
swelling

Individual supplements* of Stem Cure Formula Joint Support clinically proven safety
 


Stem Cure Formula® Joint Support is a blend of a probiotic and natural supplements consisting of Lactobacillus rhamnosus, Curcumin, Ginger, Vitamin D and Boswellia Extract.  

Multiple scientific studies demonstrate the individual components in Stem Cure Formula® protects the cells and tissues. Stem Cure Formula® Joint Support revolutionizes current thought and approach to supporting joint health.

PROBIOTIC, LACTOBACILLUS RHAMNOSUS

probiotic

Lactobacillus rhamnosus is a unique probiotic strain that has been studied extensively in the medical literature. 2162919018181732

Lactobacillus rhamnosus attenuates various types of Arthritis. 22484803

Lactobacillus rhamnosus functions as anti-oxidant which may aid health of cartilage cells. 19660542

Lactobacillus rhamnosus decreases inflammatory cytokines such as TNF-α which may prevent damage to cartilage and joint. 12675685

Lactobacillus rhamnosus has even shown ability to turn off inflammatory genes which cause pain and stiffness in Arthritis. 21499799

Lactobacillus rhamnosus has beneficial effect in Rheumatoid arthritis. 21629190

Multiple scientific studies demonstrate the individual components in Stem Cure Formula® protects the cells and tissues. Stem Cure Formula® Joint Support revolutionizes current thought and approach to supporting joint health.

CURCUMIN

Curcumin

Curcumin extract was found to be safe and equally effective as NSAID in treatment of osteoarthritis of knee. 19678780

Curcumin reduces inflammatory cytokines on cartilage. 24555068  

Curcumin functions anti-inflammatory. 23136720

Curcumin promotes cartilage formation from mesenchymal stem cells. 20594343

Curcumin has demonstrated anti-arthritic effect in animal model. 24138213

Curcumin reduces inflammation in the synovial lining of human joints. 23347846

Curcumin protects against collagen-induced arthritis. 23184090

Curcumin has therapeutic effect for treatment of osteoarthritis. 23487030

Multiple scientific studies demonstrate the individual components in Stem Cure Formula® protects the cells and tissues. Stem Cure Formula® Joint Support revolutionizes current thought and approach to supporting joint health.

 

GINGER

Ginger therapy has demonstrated a marked relief of osteoarthritis symptoms and appears safe over the long term. 24476702

Ginger protects joint inflammation by reducing inflammatory cytokines in rheumatoid arthritis. 23819216

Ginger has demonstrated in-vitro study in osteoarthritis and rheumatoid arthritis to be as effective as the powerful steroid, betamethasone. 23365744

Ginger has demonstrated in human clinical studies to be as effective as diclofenac (NSAID) with less side effects (stomach irritation). 22784345

Ginger has antioxidant and protective effects against acetaminophen as demonstrated in this animal study. 23927622

Multiple scientific studies demonstrate the individual components in Stem Cure Formula® protects the cells and tissues. Stem Cure Formula® Joint Support revolutionizes current thought and approach to supporting joint health.

VITAMIN D

Vitamin D levels positively associated with improved knee cartilage volume. 19404958

Vitamin D receptor regulates inflammation in osteoarthritic cartilage. 11467890

Vitamin D receptor regulates inflammation in rheumatoid arthritis

model. 21415051

Vitamin D appears to mediate anti-inflammatory action on synovial lining cells beneficially. 24348674

Vitamin D levels are directly associated with bone mineral density. 20718769

Longitudinal BMD loss is associated with progressive cartilage loss in knees with OA. 23494470

Multiple scientific studies demonstrate the individual components in Stem Cure Formula® protects the cells and tissues. Stem Cure Formula® Joint Support revolutionizes current thought and approach to supporting joint health.

BOSWELLIA EXTRACT

Boswellia Extract provides significant improvements in pain score and functional ability in osteoarthritis. 12622457

Boswellia Extract reduces pain and improves physical functioning in osteoarthritis patients. 24469975

Boswellia Extract is an immune-modulator and reduces Th17 differentiation. 12622457

Boswellia mix blocks inflammation related cartilage matrix breakdown, increases aggrecan and type II collagen in human osteoarthritis chondrocytes. 21854562

Boswellia Extract modulates immune system. 20696559

Boswellia Extract inhibits inflammation differently than NSAID, can be safe alternative. 17024588

Boswellia Extract derivative inhibits cartilage degrading enzyme (MMP) and regulates inflammation (ICAM-1) in human osteoarthritis study. 21060724

Boswellia Extract has anti-inflammatory, anti-arthritic and analgesic activity. 12622457

Boswellia Extract in a randomized double blinded placebo controlled study demonstrated statically significant and clinically relevant improvements (all patients had decreased knee pain, increased knee flexion and walking distance) in patients with osteoarthritis knee. 12622457

Boswellic acid down regulates gene expression of fat formation in adipocytes. 23313487

Boswellia Extract has anti-arthritic and anti-inflammation effects via suppression of pro-inflammatory cytokines. 15970410

Boswellia Extract has potent anti-inflammatory properties both in vitro as well as in vivo. 16677108

Boswellia Extract decreases joints inflammation and spinal arthritis in animal model. 14994484

Oral and topical boswellic acid attenuates mouse osteoarthritis. PMC3992997



STEM CURE FORMULA® JOINT SUPPORT and You!

Inflammation plays a pivotal role in all arthritic conditions. Both osteoarthritis and rheumatoid arthritis are inflammatory conditions. The immune system is responsible for controlling inflammation.  Individual supplements in Stem Cure Formula® Joint Support have been shown to function as immune-modulators and reduce T-helper 17 (Th-17) differentiation.  Although many patients will begin to see improvement within a few days to weeks with these treatments, it is important to realize that the response to inflammation can take months to downregulate maximally.  For patients with RHEUMATOID ARTHRITIS and other AUTOIMMUNE JOINT DISORDERS where the body develops antibodies to itself and ultimately attacks itself, the T-helper 17 (Th-17) cells play an instrumental role in the inflammatory condition and disease process. Th-17 cells are a subset of T-helper cells that produce interleukin (IL)-17. Interleukin-17 is an inflammatory cytokine which results in destructive tissue damage to the cartilage and joint. Individual supplements in Stem Cure Formula® Joint Support have been shown to function as immune-modulators and reduce Th-17 differentiation.  Because the Th-17 can live up to six months and pass along their programmed cellular destruction into memory cells. The improvement for rheumatoid arthritis and other autoimmune joint disorders may take longer. For this reason, it is STRONGLY RECOMMENDED that customers try STEM CURE FORMULA® JOINT SUPPORT "daily" for at least 3 months.

 

Stem Cure Formula® Joint Support

Contains: Vitamin D, Lactobacillus rhamnosus, Curcumin, Boswellia Extract, Ginger Each serving contains 10 billion live cells at time of manufacture.Other Ingredients: Hypromellose (Capsule), Rice Flour, Magnesium Stearate. Contains:  Milk (2.3 parts/million)

Click for our Joint Support product brochure